Christopher vakoc

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August undefined, 2024

WebMar 15, 2024 · Here, we used a domain-focused CRISPR screen to reveal an essential role for LKB1 and its Salt-Inducible Kinase effectors (SIK3, in a partially redundant manner with SIK2) to maintain MEF2C function in acute myeloid leukemia (AML). A key phosphorylation substrate of SIK3 in this context is HDAC4, a repressive cofactor of MEF2C. WebApr 17, 2015 · Vakoc is being recognized for his groundbreaking discoveries in the areas of epigenetics and cancer biology. His research on the basic molecular mechanisms that …

Targeting Transcription Factors in Cancer - PubMed

WebETV6 dependency in Ewing sarcoma by antagonism of EWS-FLI1-mediated enhancer activation. Nat Cell Biol. 2024 Jan 19. doi: 10.1038/s41556-022-01060-1. WebApr 12, 2024 · Engrailed-1 (EN1) is a critical homeodomain transcription factor (TF) required for neuronal survival, and EN1 expression has been shown to promote aggressive forms of triple negative breast cancer. Here, we report that EN1 is aberrantly expressed in a subset of pancreatic ductal adenocarcinoma (PDA) patients with poor outcomes. EN1 … cheo hospital website

Addgene: LentiV_Cas9_puro

WebApr 12, 2024 · EN1 predominantly repressed its target genes through direct binding to gene enhancers and promoters, implicating a role in the acquisition of mesenchymal cell … WebThe Vakoc Laboratory Cancer Drug Target Discovery and Mechanisms Our lab seeks to discover drug targets by applying genetic screens to human cancer cells. This genetic … WebFeb 24, 2024 · Vakoc and his colleagues became excited about ETV6 when their experiments revealed that Ewing sarcoma cells seem uniquely dependent on this protein. “This protein is present in all cells. But... cheo house 2021

BRD9-Hemmstoffe greifen Leukämieantreiber an - medonline

An epigenetic tipping point in cancer comes under the …

WebMartyna W. Sroka & Christopher R. Vakoc Two studies show that some cancers are driven by genetic changes in the NSD3 protein that alter its enzymatic activity. Biochemical and structural characterization hints at a route to pharmacological reversal. See p.498 & p.504 Gene expression is dynamic, but tightly regulated. Cells use a variety of ... WebMay 12, 2015 · Led by Junwei Shi and Christopher Vakoc, the researchers designed CRISPR/Cas9 systems to knock out 192 specific protein domains in five chromatin regulator genes (rather than knock out the entire gene) to find those essential to the survival of acute myeloid leukemia cells. They found 25 domains without which cancer cells could not … flights from chs to fllWebVakoc’s team demonstrated that chemical inhibition of BRD4 exhibits therapeutic effects in mouse models of leukemia, a finding that has motivated ongoing clinical trials in human … flights from chs to fort myers

"WebPlasmid pHAGE_puro from Dr. Christopher Vakoc's lab is published in Cancer Cell. 2024 Dec 10;34(6):970-981.e8. doi: 10.1016/j.ccell.2024.10.015. Epub 2024 Nov 29. This plasmid is available through Addgene. Image: Illustrated plasmid map in PNG format. GenBank File: Plasmid sequence and annotations. Use text editor or plasmid mapping software to ... " - Christopher vakoc

Christopher vakoc

Selective inhibition of tumor oncogenes by disruption of super ...

WebChristopher R. Vakoc's 203 research works with 19,068 citations and 12,570 reads, including: ETV6 dependency in Ewing sarcoma by antagonism of EWS-FLI1-mediated enhancer activation WebJan 19, 2024 · New treatments are badly needed, says CSHL Professor Christopher Vakoc, who led the research on ETV6. Vakoc and his colleagues became excited about ETV6 when their experiments revealed that...

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WebHuman Kinase Domain-Focused CRISPR Knockout library was a gift from Christopher Vakoc (Addgene #117725) LKB1, Salt-Inducible Kinases, and MEF2C Are Linked Dependencies in Acute Myeloid Leukemia. Tarumoto Y, Lu B, Somerville TDD, Huang YH, Milazzo JP, Wu XS, Klingbeil O, El Demerdash O, Shi J, Vakoc CR. WebFeb 18, 2024 · New treatments are badly needed, says CSHL Professor Christopher Vakoc, who led the research on ETV6. When scientists blocked a protein called ETV6 in Ewing sarcoma cancer cells (left), they reverted back to normal connective tissue cells (right), which dramatically changed their shape, size, and behavior. Credit: Vakoc …

WebChristopher R. Vakoc, Ph.D. - Publications Affiliations: 2008- Cold Spring Harbor Laboratory, Cold Spring Harbor, NY Area: Molecular Biology Tree Info Grants Similar researchers PubMed Report error 119 high-probability publications. We are testing a new system for linking publications to authors. You can help! WebOct 25, 2024 · CSHL Professor Christopher Vakoc and his lab discovered that acute myeloid leukemia cells depend on a single transporter to get the essential sugar inositol …

WebMay 16, 2024 · Christopher R. Vakoc Nature 607 , 169–175 ( 2024) Cite this article 9650 Accesses 10 Citations 150 Altmetric Metrics Abstract Tuft cells are a rare chemosensory … WebChris Vakoc. Cancer Center Member. Professor Harold and Florence & Ethel McNeill Professor of Cancer Research Cancer Center Program Co-Leader. signal transduction, Ras and Rho proteins, tumorigenesis, …

WebSep 1, 2015 · Anand S Bhagwat 1 , Christopher R Vakoc 1 Affiliation 1 Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA. PMID: 26645049 PMCID: PMC4669894 DOI: 10.1016/j.trecan.2015.07.001 Abstract Transcription factors (TFs) are commonly deregulated in the pathogenesis of human cancer and are a major …

WebChristopher Vakoc Tarumoto et al LentiV_Cas9_puro LentiV_Cas9_puro (Plasmid #108100) Print Enlarge View all sequences Purpose Lentiviral expression plasmid of spCas9 with puromycin resistance gene Depositing Lab Christopher Vakoc Publication Tarumoto et al Mol Cell. 2024 Feb 28. pii: S1097-2765 (18)30109-6. doi: … cheoh wee keatWebChristopher Vakoc Publication Huang et al. Genes Dev. 2024 Jul 1;32 (13-14):915-928. doi: 10.1101/gad.314815.118. ( How to cite ) Ordering Available to Academic and Nonprofits Only † A Cas9 plasmid is NOT included with this item and will have to … flights from chs to ft lauderdaleWebJun 5, 2014 · Junwei Shi 1 , Christopher R Vakoc 2 Affiliations 1 Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA; Molecular and … cheo hr contactWebChristopher Vakoc, MD, PhD, is a professor at Cold Spring Harbor Laboratory. His research is focused on gene regulation, specifically determining how certain genes drive cancer growth and looking for ways … cheo home lottery homeWebMeet Dr. Christopher Vakoc Inventing new cancer medicines Cancer cells achieve their pathogenicity by changing which genes are on and off. To maintain these changes in gene expression, cancer cells rely on proteins that interact with DNA or modify chromatin. cheo house 2022WebChristopher R. Vakoc, MD, PhD. 1997-2001, B.S., The Pennsylvania State University. 2011-2015, Assistant Professor at Cold Spring Harbor Laboratory. 2015-2024, Associate … flights from chs to hartford ctWebFeb 22, 2024 · ISSN 2405-8033 (Print) Roe, Jae-Seok, Mercan, Fatih, Rivera, Keith, Pappin, Darryl J, Vakoc, Christopher R (June 2015) BET Bromodomain Inhibition Suppresses the Function of Hematopoietic Transcription Factors in Acute Myeloid Leukemia. flights from chs to hou