WebHere, we determined the cryo-EM structures of human SMG1 at 3.6 Å resolution and the SMG1-SMG8-SMG9 complex at 3.4 Å resolution, respectively. SMG8 has a C-terminal kinase inhibitory domain (KID), which covers the catalytic pocket and inhibits the kinase activity of SMG1. WebUsing cryo–electron microscopy (cryo-EM), we determined the structure of human cohesin bound to its loader NIPBL and DNA at medium resolution. Cohesin and NIPBL interact extensively and together form a central tunnel to entrap a 72–base pair DNA. NIPBL and DNA promote the engagement of cohesin’s ATPase head domains and ATP binding.
Sensory specializations drive octopus and squid behaviour
Web2 days ago · We first determined the structure of squid CRB1 in a complex with denatonium using single-particle cryo-EM (Fig. 3a–c and Extended Data Figs. 5 and 6). … Web8B7Q: Cryo-EM structure for the mouse LEPR-CRH2:Leptin:LEPR-Ig complex following symmetry expansion in combination with local refinement. PDB ID: 8B7Q Download: MMDB ID: 228661: PDB Deposition Date: 2024/9/30: Updated in MMDB: 2024/04: Experimental Method: electron microscopy. Resolution: most economical building method
Bottom-up structural proteomics: cryoEM of protein complexes ... - Nature
WebOct 13, 2024 · The work marks the first such structure determined using the university's $17 million cryo-electron microscopy (cryo-EM) facility that opened last year. … WebJul 26, 2024 · Protein homeostasis in plastids is strategically regulated by the protein quality control system involving multiple chaperones and proteases, among them the Clp protease. We determined the structure of the chloroplast ClpP complex from Chlamydomonas reinhardtii by cryo-EM. ClpP contains two heptameric catalytic rings without any … WebMay 28, 2024 · Cryo-EM structures tell a tale of two telomerases Nicholas M. Forino, Jendrik Hentschel & Michael D. Stone Nature Structural & Molecular Biology 28 , 457–459 ( 2024) Cite this article 2073... miniature robotics parts