WebIRF8 deficiency has a variable effect upon the development of cDC2. They may be depleted by biallelic loss of IRF8, ... Moreover, it has been demonstrated that IRF-4 binds directly to the promoter of the zbtb20 gene, whose function will be described in Section 3 (Chevrier et al., 2014). Further studies will be necessary to fully unravel the ... WebAug 8, 2007 · The GAPDH promoter was analysed as a negative control for IRF8. Data represent mean ± s.e.m. of quadruplicate real-time PCR. Full size image Next, we investigated the expression of CHRNA1 ex...

Interferon regulatory factor 8 regulates caspase-1 expression to ...

WebMar 18, 2010 · A reporter construct with the IRF8 promoter was repressed by WT1, dependent on a putative WT1-response element. Binding of WT1 to the IRF8 promoter was demonstrated by chromatin... WebIRF-4 is a member of the interferon regulatory factor (IRF) family of transcription factors, … irshath tamil murasu

IRF8 Gene - GeneCards IRF8 Protein IRF8 Antibody

WebThe IRF8 promoter was found to interact with its flanking enhancers already at the CDP stage, and then more frequent interactions with its upstream and downstream sequences were found in pDC and cDC1, respectively. Interestingly, we identified a novel long non-coding RNA (lncRNA) transcribed from the +32 kb enhancer downstream of IRF8 ... In myeloid cells, IRF8 regulates the expression of Bax and Fas to regulate apoptosis. In chronic myelogenous leukemia (CML), IRF8 regulates acid ceramidase to mediate CML apoptosis. IRF8 is highly expressed in myeloid cells and was originally identified in as a critical lineage-specific transcription factor for myeloid cell differentiation, recent studies, however, have shown that IRF8 is also constitutively expressed in non-hematopoietic cancer cells, albeit at a lower leve… irshdc