Klf2 endothelial cell

Author: ctxc

August undefined, 2024

WebFeb 5, 2024 · KLF2 is a member of the Kruppel-like transcription factor family of proteins containing highly conserved DNA-binding zinc finger domains. KLF2 participates in the differentiation and regulation of the functional activity of monocytes, T lymphocytes, adipocytes, and vascular endothelial cells. WebApr 11, 2024 · To systematically dissect the transcriptomic differences between homeostasis and chronic dry skin at the single-cell level, we carried out scRNA-seq on two biological mixed samples from each group, and each mixed sample contained three mice (Fig. 1 A).After quality control, we obtained 18,578 cells in the AEW groups and 24,160 …

Tumor Necrosis Factor Alpha-Mediated Reduction of KLF2 Is …

WebJan 1, 2024 · Background & Aims. The transcription factor Krüppel-like factor 2 (KLF2), inducible by simvastatin, confers endothelial vasoprotection. Considering recent data … WebMay 25, 2024 · Kruppel-like factor 2 (KLF2) is a laminar flow-inducible transcription factor primarily expressed by endothelial cells that play an important role in the regulation of endothelial function [3,4]. Studies have shown that KLF2 induces eNOS expression and increases NO production in cultured human umbilical vein endothelial cells (HUVECs) and … raining weekend funny images

MicroRNA‐374b induces endothelial‐to‐mesenchymal transition …

WebLung Kruppel-like factor/KLF2 is highly expressed in the vascular endothelium (17). Systemic knockout of KLF2 results in embryonic death and abnormal vessel formation (17, 18). However, our understanding of the function and targets of KLF2 in endothelial biology have been lacking to date. We recently identiﬁed KLF2 as a novel transcriptional reg- WebMar 4, 2024 · While endothelial KLF2 and endothelium-derived KLF2-induced miRNAs have homoeostatic, anti-proliferative effect on vascular endothelial and smooth muscle cells, direct activation of KLF2 in ... WebFeb 23, 2024 · Inducible endothelial-specific deletion of Klf2 and/or Klf4 reveals that a single allele of either gene is sufficient for survival, but absence of both (EC-DKO) results … outriders wellspring

KLF2 and KLF4 control endothelial identity and vascular …

KLF2 provokes a gene expression pattern that establishes …

WebJun 23, 2024 · The protein levels of endothelial markers (PECAM1 [platelet endothelial cell] adhesion molecule-1 and VE-Cadherin) were reduced in human umbilical vein ECs (HUVECs) with KLF2 knockdown. The … WebNational Center for Biotechnology Information raining whiskeyWebThe large family of KLFs in humans includes 18 members, among which KLF2 and KLF4 are at the crossroads between endothelial cell mechanobiology and immunometabolism, which play important roles in ... raining windom hd gif

"WebKLF2orchestrates vascular homeostasis and serves as a key molecular switch between proinflammatory atheroprone and quiescent atheroresistant endothelial phenotype. This characteristic is attributed to its ability to activate atheroprotective and inhibit atherogenic endothelial transcription programs. " - Klf2 endothelial cell

Klf2 endothelial cell

Role of Krüppel-Like Transcription Factors in Endothelial …

WebFeb 2, 2024 · KLF2 and KLF4 control endothelial identity and vascular integrity - PMC Back to Top Skip to main content An official website of the United States government Here's how you know The .gov means it’s official. Federal government websites often end in .gov or .mil. sharing sensitive information, make sure you’re on a federal WebApr 30, 2024 · Expression of KLF2 by endothelial cells is known to exert protective effects against atherosclerosis, however OSS greatly reduces expression of KLF2 at both the mRNA and protein levels. To determine whether GPR30 plays a role in OSS-induced downregulation of KLF2, HAECs were exposed to OSS (± 5 dyn/cm 2 ) in the presence or absence of 5 and …

Did you know?

WebMay 5, 2004 · Overexpression of KLF2 in umbilical vein endothelial cells robustly induced endothelial nitric oxide synthase expression and total enzymatic activity. In addition, KLF2 … WebApr 10, 2024 · Understanding the endothelial cell function in vascular biology has been pivotal for grasping the repair mechanisms in ischaemic tissue and during cardiovascular diseases. ... endothelial miR-92a is regulated by the master EC transcription regulator KLF2, and its expression increased in arterial regions where complex hemodynamic conditions …

WebOur studies suggest that endothelial Klf2 is expressed in response to fluid shear forces and is required for vascular hemodynamic regulation during development, but they do not … WebMar 4, 2024 · Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension - PMC Back to Top Skip to main content An official website of the United States government Here's how you know The .gov means it’s official. Federal government websites often end in .gov or .mil.

WebInterestingly, KLF2 inhibits endothelial cell activation by diverse proinflammatory stimuli, including interleukin (IL)-1β, tumor necrosis factor (TNF)α, lipopolysaccharide, and … WebApr 13, 2024 · For instance, activation of the MEK5/ERK5/KLF2 pathway by fluid shear stress in endothelial cells has recently been shown to require mROS production (Coon et al., J Cell Biol (2024) 221 (7): e202409144). By contrast, Abe’s group observed that H2O2 stimulation could enhance ERK5 phosphorylation but inhibited ERK5-mediated gene expression (e.g ...

Webactivating protein-1 (AP-1) and NF-κB in human endothelial cells and VSMCs [48], probably mediated by Rho and Rac Attenuation of Inflammatory Damage proteins [49, 50]. Further study shows that statins suppress Inflammatory processes have a key role in the the activation of NF-κB probably through inducing the pathophysiology of ischemic stroke ...

WebJan 24, 2024 · Kruppel like factor 2 (KLF2) is a mechanosensitive transcription factor participating in the regulation of vascular endothelial cells metabolism. Activating KLF2 in endothelial cells induces eNOS … raining while the sun is out superstitionWebFeb 14, 2013 · Krüppel-like factor 2 (KLF2) is expressed in endothelial cells in the developing heart, particularly in areas of high shear stress, such as the atrioventricular (AV) canal. KLF2 ablation leads to myocardial thinning, high output cardiac failure and death by mouse embryonic day 14.5 (E14.5) in a mixed genetic background. raining while sun shining saying outriders when does tiago resetWebWe recently reported the observation that KLF2 is a potent inducer of endothelial nitric oxide synthase, a key regulator of vessel biology. 16 To gain greater insight into additional … outriders wellspring secretWebJul 28, 2024 · Endothelial cells (ECs) are professional mechanosensing cells that constantly perceive and respond to the hemodynamic forces generated by blood flow. 1 The hemodynamic forces play a critical role in the development and geometric distribution of atherosclerosis, 2 a leading cause of death in patients with stroke and myocardial … raining while campingWebcultured endothelial cells, where it regulates a large number of vasoactive endothelial genes. Here, we show that Klf2 expression during development mirrors the rise of fluid shear forces, and that endothelial loss of Klf2 results in lethal embryonic heart failure due to a high-cardiac-output state. raining window night stockWebMar 31, 2024 · Gimbrone MA Jr, Garcia-Cardena G. Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis. Circ Res. 2016 Feb 19;118(4):620-36. doi: 10.1161/CIRCRESAHA.115.306301. outriders what does ash do