Paraptotic cell death
WebNov 15, 2024 · Here, we review the molecular mechanisms underlying paraptotic cell death, as well as the natural products inducing this kind of cell death program. A better understanding of paraptosis should facilitate the development of new therapeutic strategies for cancer prevention and treatment. WebSep 12, 2024 · The induction of paraptotic cell death is emerging as a potential direction for antitumor therapy. 21 To date, numerous natural compounds have been identified as …
Paraptotic cell death
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WebApr 18, 2003 · The paraptotic cell death resulting from activation of the transfected VR1 receptors resembles ischemia/reperfusion or excitotoxic damage found in excitable tissues, which possess mechanisms for massive Ca 2+ entry. The emerging inference is that the type of stress a cell undergoes determines the cell death response (apoptosis, … WebJul 11, 2024 · Apoptosis, a type of programmed cell death (PCD), is a biological process through which unwanted cells are eliminated in …
WebOct 1, 2024 · It can induce paraptotic cell death with cytoplasmic vacuolation that stems from the expansion of mitochondria and endoplasmic reticulum in cells of the BC3H1 myoblast cell line [104, 105]. Furthermore, 1-desulfoyessotoxin can also induce paraptotic cell death, which is an analog of yessotoxin. WebDec 3, 2012 · Regulated cell death is a key process in plant and animal development, but does it occur in parasitic protozoa? Jeremy Mottram and colleagues assess the evidence …
WebThe copper(II) complex A0 induces a type of non-apoptotic cell death also known as paraptosis. Paraptosis involves extensive endoplasmic reticulum vacuolization in the absence of caspase activation. A wide panel of human cancer cell lines was used to demonstrate differences in cytotoxicity by the paraptosis-inducing drug A0 and the metal … WebJan 12, 2024 · The term “paraptosis-like cell death” has been used to describe the types of cell death accompanied by the dilation of either the mitochondria or the ER alone or …
WebSep 13, 2024 · The cells were then analyzed for their DNA content by flow cytometry (Agilent Novocyte Quanteon). For cell death analysis MDA-MB-231 and MCF7 cells were seeded in 60 mm dishes at a density of 5 ... It was reported that proteasomal dysfunction and ER stress regulate paraptotic cell death in cancer cells [Fontana F. Raimondi M. Marzagalli …
WebOct 15, 2024 · Paraptotic cell death is frequently associated with changes of mitochondrial morphology and functionality 21,22,23,24,25,26,27. Consequently, JC-1 staining was … picture of shower headWebThe clioquinol derivative 8-hydroxoquinoline increases intracellular free copper in the cytoplasm, leading to paraptotic cell death in HeLa and PC3 cancer cells [232,233]. Clioquinol binds with copper and subsequently induces apoptosis by blocking the activity of the 20S proteasome [234] or inhibiting HDAC (histone deacetylase) activity in ... picture of shower nicheWebAug 17, 2016 · Overexpression of CHOP, activation of MAPKs (P38, JNK, and ERK) and massive cytoplasmic vacuolisation collectively suggest a paraptotic mode of cell death induced by proteasomal dysfunction as well as endoplasmic reticulum and … top gear ed sheeranWebCyclometalated iridium(iii) complexes induce mitochondria-derived paraptotic cell death and inhibit tumor growth in vivo ... Among the ROS, superoxide anion radicals play a … picture of shower curtainWebCONCLUSIONS: The present study indicates that paraptotic-like cell death may occur in parasitic flatworms (Neodermata). The presence of GER-bodies in mature vitellocytes indicates close relationship between the Diphyllobothriidea, Caryophyllidea and Spathebothriidea, which are considered as the earliest evolved groups of the Eucestoda. ... picture of shri ramWebJul 11, 2024 · Apoptosis, a type of programmed cell death (PCD), is a biological process through which unwanted cells are eliminated in multicellular organisms. In most cells, … top gear electricWebSep 16, 2024 · Some studies have shown that honokiol can induce cell death through paraptosis induction when treated as a single drug or combined with imatinib in leukemia cells [ 20, 21 ], indicating that paraptosis may be honokiol induced, another mode of programmed cell death. picture of shrimp