Phosphotyrosine binding domain
WebMar 16, 2024 · Tyrosine kinases and SH2 (phosphotyrosine recognition) domains have binding specificities that depend on the amino acid sequence surrounding the target (phospho)tyrosine residue. WebThe pY motifs created by tyrosine kinases serve as high-affinity binding sites for the recruitment of cytoplasmic or membrane-associated proteins that contain either an SH2 domain or PTB (phosphotyrosine-binding) domain. SH2 domains are ~100 amino acids in …
Phosphotyrosine binding domain
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WebPhosphotyrosine (P.Tyr) residues on activated RTKs are recognized by a phosphodependent-binding domain, the SH2 domain. The recruitment of SH2 domain proteins to autophosphorylated RTKs at the plasma membrane is essential for initiating and propagating downstream signaling. WebPhosphotyrosine-Binding (PTB) Domain In general, PTB domains play a role similar to SH2 domains ( Gustafson et al., 1995 ). Based on ligand recognition, PTB domains fall into two …
WebPTB Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain There are 18492 PTB domains in 16250 proteins in SMART's nrdb database. Click on the following links for more information. Evolution (species in which this domain is found) Cellular role (predicted cellular role) Literature (relevant references for this domain) WebOct 1, 1999 · Phosphotyrosine binding (PTB) domains have been identified in a large number of proteins. In proteins like Shc and IRS-1, the PTB domain binds in a phosphotyrosine …
WebThe phosphopeptide binding site is a bipartite pocket on the surface of the SH2 domain. One part of the pocket is lined by conserved basic amino acid residues and binds the … WebApr 22, 2005 · Here we show that the C2 domain of PKCδ is a phosphotyrosine binding domain. We determine its specificity by peptide library screens, its affinity by isothermal titration calorimetry, and the structural basis for phosphotyrosine binding by X-ray diffraction of its crystal structure.
WebTyrosine phosphorylation by PTKs creates binding sites for SH2 domains that specifically recognize the phosphotyrosine moiety. Therefore, proteins containing SH2 domains can be recruited to the site of phosphorylation and signaling complexes can be formed in a phosphotyrosine-dependent manner ( 1 , 2 ).
WebMar 5, 2024 · Conserved Domains (3) summary cd07631 Location: 20 → 234 BAR_APPL1; The Bin/Amphiphysin/Rvs (BAR) domain of Adaptor protein, Phosphotyrosine interaction, PH domain and Leucine zipper containing 1 cd13158 Location: 490 → 625 small house ornamentsWebWe demonstrate that the phosphotyrosine binding domain of Shc is necessary and sufficient for its association with tyrosine-phosphorylated SHIP. Through site-directed mutagenesis, we have identified two tyrosines on SHIP, Tyr-917, and Tyr-1020, as the principal contact sites for the Shc- phosphotyrosine binding domain. high wbc urine countWebAug 7, 1998 · EGFR binding of Shc proteins results in their tyrosine phosphorylation and subsequent activation of the Ras and Erk pathways. Shc interaction with activated … small house outdoor christmas lightsWebApr 27, 2016 · National Center for Biotechnology Information high wbc urine meaningWebFeb 26, 2003 · These motifs are part of a canonical recognition sequence for phosphotyrosine-binding (PTB) domains, protein modules that are present in a wide … small house pets that don\u0027t smellWebJun 11, 2014 · Hakai acts through its phosphotyrosine-binding (HYB) domain, which bears a dimeric fold that recognizes the phosphotyrosine motifs of E-cadherin, cortactin, DOK1, … small house pets that don\\u0027t smellWebApr 25, 2014 · Phosphorylation of proteins is well established as a dominant mechanism of signal transduction in eukaryotic cells. 1 Phosphorylation occurs in response to extracellular and intracellular signals, and the modified protein can then be sensed by sequence-specific modular binding domains. 2 These include SH2 and PTB domains, which bind … small house parks